SYNM — Synemin
SYNM belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SYNM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Cytoskeletal Scaffold Cytoskeletal | ADD3, ANTXR2, CTSD, EPB41L2, FXYD6, GYPC, MAP4K2, NRP2 +2 more | View in SCUBA |
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A +6 more | |
| Glial cells | Glial RNA Homeostasis RNA processing & translation | ATRX, DYNC1H1, GTF2I, NCL, RBM25, SCN9A, SRSF11 | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2 +8 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NET1, NRGN, PALLD, PLN, RERGL, SYNE1 +2 more | View in SCUBA |
About the gene
| Synonyms | DMN, KIAA0353, SYN |
|---|---|
| Chromosome | 15: 99098217-99135593 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.