ZFHX3 — Zinc finger homeobox 3
ZFHX3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZFHX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | ACAA2, CAT, CRYBG1, GLIPR2, MLXIP, PKDCC, SAMD5, SEMA6A | View in SCUBA |
| Lymphatic endothelial | Actomyosin Contractility Cytoskeletal | AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A +6 more | View in SCUBA |
| Macrophages | Myeloid Receptor Signaling Innate immunity | ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15 +29 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NET1, NRGN, PALLD, PLN, RERGL, SYNE1 +2 more | View in SCUBA |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, EBF1, FRMD4A, FRY, ITGA7, LGALSL, LGI4, MCAM +6 more | View in SCUBA |
About the gene
| Synonyms | ATBF1, C16orf47, FLJ26184, ZNF927 |
|---|---|
| Chromosome | 16: 72782885-73891871 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Myogenesis, Transcription, Transcription regulation |
Function
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.