PALLD — Palladin, cytoskeletal associated protein
PALLD belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PALLD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, ELN, FBLN2, FGF18 +5 more | View in SCUBA |
| Enterocytes | Focal adhesion actin Migration & adhesion | BAZ2B, CARMIL1, COP1, FRYL, KIF13A, LPP, MYO6, PTK2 +4 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Cytoskeletal | APLP2, ARHGAP18, BDKRB2, CACNA1H, CAV1, CAV2, CD9, CPED1 +10 more | View in SCUBA |
| Gamma-delta T cells | Tissue-resident gd T Tissue residence | AKR1C3, ASCL2, BFSP1, CARNS1, CD320, CES1, CMKLR1, CTBP2 +21 more | |
| Hematopoietic progenitor cells | Naive B Cell Lymphcyte development | CCR7, CLNK, DYRK2, EVL, FCMR, HLX, IGHD, IGHM +4 more | |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NET1, NRGN, PLN, RERGL, SYNE1, SYNM +2 more | View in SCUBA |
| Smooth muscle cells | Actin Cytoskeletal Scaffold Cytoskeletal | ACTN4, ATP2B4, ATRX, DDX5, DLGAP4, EIF4G2, FAT1, GNAI2 +13 more | View in SCUBA |
About the gene
| Synonyms | CGI-151, KIAA0992, SIH002 |
|---|---|
| Chromosome | 4: 168497052-168928457 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.