NRGN — Neurogranin
NRGN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NRGN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Platelet Biogenesis Myeloid development | CAVIN2, CCL5, CMTM5, F13A1, GNG11, GP9, MAP3K7CL, PF4 +6 more | |
| Monocytes | Granulocytic Differentiation Developmental | CSF3R, GLT1D1, HEBP2, NDUFB9, PLP2, PNPLA2, PXN, SMARCD3 +2 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NET1, PALLD, PLN, RERGL, SYNE1, SYNM +2 more | View in SCUBA |
| Smooth muscle cells | Wnt-Notch Modulation Development | CLMN, FRZB, HES4, LBH, MAP3K7CL, NET1, NRIP2, PHLDA2 +1 more | View in SCUBA |
About the gene
| Synonyms | RC3 |
|---|---|
| Chromosome | 11: 124739942-124747210 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Calmodulin-binding |
Function
Acts as a 'third messenger' substrate of protein kinase C- mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.