ADGRE2 — Adhesion G protein-coupled receptor E2
ADGRE2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADGRE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NFAT-cAMP Signaling Inflammatory | ACKR3, ANKRD28, CHSY1, CREM, ELL2, FRMD4A, GPCPD1, RCAN1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | HOX HSC Program Stemness | AFF1, ARHGAP25, HOXA3, HOXA6, HOXA9, JAML, LPIN1, MOB1B +3 more | |
| Monocytes | Monocyte-Macrophage Differentiation Developmental | ADGRE3, BID, CYSLTR2, FAM110A, HES4, MARCKSL1, NRARP, PRELID1 +4 more | View in SCUBA |
About the gene
| Synonyms | CD312, EMR2 |
|---|---|
| Chromosome | 19: 14732392-14778560 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Cell adhesion, Inflammatory response |
Function
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.