CHSY1 — Chondroitin sulfate synthase 1
CHSY1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHSY1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | CCRL2, CDC42EP3, CGAS, CYTH1, HES5, HIPK3, ID1, ID3 +7 more | View in SCUBA |
| Fibroblasts | NFAT-cAMP Signaling Inflammatory | ACKR3, ADGRE2, ANKRD28, CREM, ELL2, FRMD4A, GPCPD1, RCAN1 +3 more | View in SCUBA |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CASP4, FNDC3B, GMFG, ITPRIPL2, LAMB1, MARCKSL1, NECTIN2, OLFML2A +5 more | View in SCUBA |
About the gene
| Synonyms | CSS1, KIAA0990 |
|---|---|
| Chromosome | 15: 101175727-101252048 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Transferase |
Function
Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.