T Cell Exhaustion
Gene co-expression module in Gamma-delta T cells
| Category | Exhaustion |
|---|---|
| Genes | 29 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
TIGIT is a canonical co-inhibitory receptor and exhaustion marker. TOX is the master transcription factor of T cell exhaustion, driving sustained expression of inhibitory receptors. IKZF2 (Helios) marks regulatory and exhausted T cells. CD8B indicates a CD8+ lineage context. PLCG2 is a TCR-proximal signaling effector. CRTAM marks recently activated cytotoxic T cells. SPRY2 provides negative feedback on activation signals. AKAP5 anchors PKA for signaling regulation. P2RY10 is a purinergic GPCR expressed in immune cells. Together TIGIT+TOX+IKZF2 form the exhaustion triad, and this module captures a chronic activation/exhaustion state in gd T cells.
Genes
AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1, DGKH, EEIG2, IKZF2, IRAG2, KMT5C, MAP1LC3A, NFIL3, OSGIN2, P2RY10, PHTF2, PHYH, PLCG2, POMC, RNF157, SFMBT2, SPRY2, TIGIT, TMEM70, TOX, TTN, ZC3H11A
Most correlated modules
- Activation Stress Response · correlation 0.91
- NK Receptor Expression · correlation 0.88
- Hypoxia Tissue Adaptation · correlation 0.84
- AHR/NF-κB Survival · correlation 0.84
- mRNA Splicing Regulation · correlation 0.81
- Chromatin Remodeling Signaling · correlation 0.81
- S-phase Proliferation · correlation 0.81
- TCR Inhibitory Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.