CD8A — CD8a molecule
CD8A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD8A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Terminal Exhaustion Exhaustion | ACP5, CARD16, CASP1, CD2, CD247, CD8B, CHST12, CXCR6 +6 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8B, CDYL, CRTAM, CYSTM1, DGKH +20 more | |
| Mucosal-associated invariant T cell | Nuclear Receptor Chromatin DNA/chromatin regulation | DDX21, DDX39A, FBRS, GNL1, NR1H2, PHF1, SQSTM1, TRABD +1 more |
About the gene
| Synonyms | CD8 |
|---|---|
| Chromosome | 2: 86784610-86808396 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T- lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.