ARFGEF1 — ADP ribosylation factor guanine nucleotide exchange factor 1
ARFGEF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARFGEF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mTOR-Exocyst Signaling TCR Signaling | ANKRD36C, CGGBP1, CTC1, DOCK11, EXOC1, EXOC4, FRYL, GSK3B +12 more | |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A, CDC73 +48 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Activation Signaling TCR Signaling | ARIH1, CARD11, CCDC88C, CD226, GLS, KANSL1, KMT5B, MAP3K2 +12 more | |
| Neutrophils | Apoptotic Neutrophil Program Developmental | ANO10, APAF1, ATF7IP, BLTP1, CEP350, FAR2, FBXW2, HIPK2 +5 more |
About the gene
| Synonyms | ARFGEP1, BIG1, DKFZP434L057, p200 |
|---|---|
| Chromosome | 8: 67173511-67343781 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Protein transport, Transport |
Function
Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturation of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competitive RhoA binding. The function in the nucleus remains to be determined.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.