TCR Activation Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
CARD11 is a core scaffold of the CBM complex (CARD11-BCL10-MALT1) downstream of TCR/BCR triggering NF-κB. PAG1 (Cbp) is a membrane adaptor that recruits Csk to suppress Src-family kinases and is a key regulator of TCR signaling threshold. STIM2 is a Ca2+ sensor in the ER triggering SOCE/NFAT. PDE7A is a cAMP phosphodiesterase expressed in T cells that modulates TCR activation. MAPK1 (ERK2) and MAP3K2 are MAPK pathway kinases. GLS (glutaminase) links TCR activation to metabolic reprogramming. WAC and KANSL1 are chromatin regulators. MYCBP2 is an E3 ubiquitin ligase. CD226 (DNAM-1) is an activating receptor on MAIT cells. WNK1 regulates T cell trafficking. NIPBL is cohesin loader. The module is strongly enriched for TCR signal transduction components.
Genes
ARFGEF1, ARIH1, CARD11, CCDC88C, CD226, GLS, KANSL1, KMT5B, MAP3K2, MAPK1, MYCBP2, NIN, NIPBL, PAG1, PDE7A, STIM2, TM9SF3, TNKS2, TOP1, WAC, WNK1
Most correlated modules
- RAS-GEF Signaling · correlation 0.83
- Circadian Transcriptional Regulation · correlation 0.81
- SWI/SNF Chromatin Remodeling · correlation 0.79
- Cellular Maintenance · correlation 0.78
- T cell Homeostasis · correlation 0.77
- Lymphocyte Migration · correlation 0.75
- T cell Transcriptional Identity · correlation 0.75
- Cytoskeletal Migration · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.