FRYL — FRY like transcription coactivator
FRYL belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FRYL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Endothelial | EC Barrier Integrity Endothelial cell development | ABCB1, ADCY4, AQP3, ARHGAP31, CRYBG3, EPS8, FGR, GULP1 +14 more | View in SCUBA |
| Enterocytes | Focal adhesion actin Migration & adhesion | BAZ2B, CARMIL1, COP1, KIF13A, LPP, MYO6, PALLD, PTK2 +4 more | View in SCUBA |
| Gamma-delta T cells | mTOR-Exocyst Signaling TCR Signaling | ANKRD36C, ARFGEF1, CGGBP1, CTC1, DOCK11, EXOC1, EXOC4, GSK3B +12 more | |
| Goblet cells | Goblet Cell Identity Epithelial development | CELF2, FOXP1, GPRIN3, HOXB13, ITPR2, KCTD12, NEDD4L, NFAT5 +5 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK11, DOCK2, ERBIN +8 more |
About the gene
| Synonyms | AF4p12, DKFZp686E205, KIAA0826, MOR2 |
|---|---|
| Chromosome | 4: 48497357-48780322 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.