HIP1R — Huntingtin interacting protein 1 related
HIP1R belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HIP1R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Hypoxia/metabolic stress Stress | ALG13, ARL4A, C9orf72, PDE4B, SC5D, SLC2A3, TENT5C, VPS37B +2 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, NR4A2, PABPC1 +18 more | View in SCUBA |
| Endothelial | Endothelial Lipid Signaling migration & adhesion | A2M, ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, PCDH1, PITPNC1 +3 more | View in SCUBA |
About the gene
| Synonyms | FLJ14000, HIP12, HIP3, ILWEQ, KIAA0655 |
|---|---|
| Chromosome | 12: 122834453-122862961 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Endocytosis |
Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.