Endothelial Lipid Signaling
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include PITPNC1 (phosphatidylinositol transfer protein, pro-angiogenic lipid signaling), PLCB1 (phospholipase C beta, lipid second messenger), ARHGEF15 (Rho GEF expressed in vascular endothelium), ADGRG1/GPR56 (adhesion GPCR), PLAU (urokinase plasminogen activator, endothelial migration/invasion), PCDH1 (protocadherin adhesion), A2M (protease inhibitor), and CYYR1 (vascular endothelial expression). The module combines phosphoinositide lipid signaling with Rho GTPase activation and cell adhesion/migration machinery. Uniform expression across subsets and modest decrease in inflammation support a homeostatic endothelial migration/lipid signaling program. Neighbor modules M25/M26 are clearly endothelial identity modules, supporting this as a related vascular functional program.
Genes
A2M, ADGRG1, ARHGEF15, CNOT6L, CYYR1, DIP2B, HIP1R, PCDH1, PITPNC1, PLAU, PLCB1, ZNF366
Most correlated modules
- Venous Endothelial Identity · correlation 0.90
- Mitophagy Stress Response · correlation 0.85
- IL-27 Receptor Signaling · correlation 0.85
- Capillary Endothelial Identity · correlation 0.84
- Endothelial Junction Identity · correlation 0.83
- Arterial EC Identity · correlation 0.80
- Endothelial Angiogenic Identity · correlation 0.79
- Integrin-Actin Adhesion · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.