ATP6V1E1 — ATPase H+ transporting V1 subunit E1
ATP6V1E1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V1E1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ECHS1, ERCC1, ETFB, GLRX3, HIGD1A +12 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8, ENY2 +28 more | View in SCUBA |
About the gene
| Synonyms | ATP6E, ATP6E2, ATP6V1E, P31, Vma4 |
|---|---|
| Chromosome | 22: 17592136-17628749 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.