ECHS1 — Enoyl-CoA hydratase, short chain 1
ECHS1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECHS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial Oxidative Stress Stress | AGTRAP, AP2M1, ECSCR, EDF1, EIF5A, NEDD8, PARK7, PHPT1 +5 more | View in SCUBA |
| Enterocytes | Oxidative Phosphorylation Mitochondrial & OxPhos | COX6A1, COX6C, DDT, HADHA, LGALS4, MGST3, NDUFA1, PRDX1 +3 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Dynamics Mitochondrial & OxPhos | ATP5MC1, EDF1, FIS1, FRA10AC1, HIGD2A, IFNAR2, MICOS13, MRI1 +2 more | |
| Goblet cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ATP5F1B, ATP5PB, CD99, COTL1, GPR160, HADH, PRDX3, SUCLG1 +1 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ERCC1, ETFB, GLRX3, HIGD1A +12 more | View in SCUBA |
| Lymphatic endothelial | Fatty Acid Oxidation Lipid metabolism | ATRAID, ECH1, ETFB, FCGRT, NDUFB10, PEBP1, PRDX2, TMEM14C | View in SCUBA |
| Macrophages | Mitochondrial OXPHOS Mitochondrial & OxPhos | APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB +28 more | View in SCUBA |
About the gene
| Synonyms | SCEH |
|---|---|
| Chromosome | 10: 133362485-133373354 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, Lyase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl- CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond. Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16. Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3- methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA). Can bind tiglyl-CoA (2- methylcrotonoyl-CoA), but hydrates only a small amount of this substrate. Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation. At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)- hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl- CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.