Proteasome UPS
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 37 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 37 genes have a known function matching the annotation |
Why this annotation
Multiple proteasome subunits are present as hub genes: PSMD7, PSMA1, PSMD2, PSMD13, PSMC1 (19S and 20S subunits), plus UBE2L3 and UBE2M (E2 ubiquitin-conjugating enzymes), RAD23A (ubiquitin receptor/proteasome shuttle), DNAJC8/DNAJC15 (HSP40 chaperones supporting proteasome function), ATP6V1E1/ATP6V1D (V-ATPase subunits), SLC25A3 (mitochondrial phosphate carrier), PFDN2 (prefoldin chaperone), SUMO1 (SUMOylation), UBE2L3/UBE2M (ubiquitin E2s). The proteasome/ubiquitin-proteasome system (UPS) is the dominant and coherent program. Neighbor modules M6 and M97 also contain proteasome subunits, confirming this is a UPS-centered neighborhood. Uniform expression is consistent with constitutive proteasome activity in macrophages.
Genes
ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8, ENY2, FAM50A, FBXW5, GHITM, HTATIP2, KGD4, LRRC59, PDAP1, PFDN2, PSMA1, PSMA3, PSMA5, PSMB5, PSMC1, PSMD13, PSMD2, PSMD3, PSMD7, RAB18, RAD23A, SLC25A3, SMIM12, SNRPB2, SRP19, STRAP, SUMO1, TXNL1, UBE2L3, UBE2M
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.99
- Mixed Housekeeping · correlation 0.97
- Proteasome UPS · correlation 0.96
- ER Protein Processing · correlation 0.95
- Glycolytic Redox Metabolism · correlation 0.95
- Protein Biogenesis · correlation 0.95
- ERAD Proteasome · correlation 0.94
- ATP Synthase Complex · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.