DNAJC8 — DnaJ heat shock protein family (Hsp40) member C8
DNAJC8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5ME, COX6A1, COX6B1, COX6C, NDUFA11, NDUFA4, NEDD8 +6 more | View in SCUBA |
| CD4⁺ T cells | RNA processing splicing RNA processing | BUD31, EDF1, EIF2S1, GTF3C6, HPRT1, ILF2, LAMTOR5, MIIP +11 more | View in SCUBA |
| CD8⁺ T cells | Nuclear RNA Splicing RNA processing & translation | CBX3, HNRNPA3, HNRNPD, HNRNPR, MAZ, PGP, PPIG, PSMD1 +5 more | View in SCUBA |
| Gamma-delta T cells | Basal Cell Maintenance Housekeeping | ARHGDIB, CYB561D2, GPAA1, INO80E, LMF2, MIF4GD, OTUB1, PCYT2 +9 more | |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DR1, EIF3I, HPRT1 +18 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, ENY2 +28 more | View in SCUBA |
About the gene
| Synonyms | SPF31 |
|---|---|
| Chromosome | 1: 28199456-28233029 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.