BRD1 — Bromodomain containing 1
BRD1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1, IRF2BP2 +19 more | |
| Mucosal-associated invariant T cell | T cell Quiescence T cell maturation | AGO2, AUTS2, BCL6, CSNK1D, DHCR7, FOXO1, GABPB1, GAL3ST2 +13 more |
About the gene
| Synonyms | BRL, BRPF2 |
|---|---|
| Chromosome | 22: 49773283-49827873 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Erythrocyte maturation |
Function
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.