FOSL2 — FOS like 2, AP-1 transcription factor subunit

FOSL2 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FOSL2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative/ER stress Stress	ASAH1, ATP6V0D1, B4GALT1, FAM210A, GEM, GZF1, HIC1, MAFG +6 more	View in SCUBA
CD4⁺ T cells	TCR early activation TCR/AP1/NFKb pathway	ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, JOSD1 +11 more	View in SCUBA
Endothelial	Chronic Inflammatory Activation Inflammation	ABL2, ADAMTS9, DDX21, EMP1, HRH1, KRT10, LMNA, PNP +2 more	View in SCUBA
Fibroblasts	Inflammatory TF Response Inflammatory	ADAMTS4, CEBPD, CMIP, KLF9, MAT2A, NR4A1, NR4A2, NR4A3 +2 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, GABARAPL1, IRF2BP2 +19 more
Goblet cells	NF-kB Inflammatory Signaling chromatin regulation & transcription	CD69, CXCR4, DDX21, DUSP2, IRF1, NFKB2, REL, RGCC +5 more	View in SCUBA
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, IRF2BP2, JOSD1 +12 more	View in SCUBA
Macrophages	NF-κB AP-1 Signaling Inflammatory	ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more	View in SCUBA
Monocytes	Wnt/AP-1 Activation Inflammatory	B4GALT1, BZW1, CHD1, CTNNB1, ETF1, GABARAPL1, GPCPD1, PNPLA8 +2 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1/MEF2 Activation T cell maturation	ADNP2, BHLHE40, CDK16, DBF4, ETF1, GADD45A, GPR35, GSPT1 +8 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, GPBP1, PDE4B, PIK3R1, RALGAPA1, SDCBP +4 more	View in SCUBA
Neutrophils	Inflammatory Resolution Stress	ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, GPR65, JOSD1 +4 more
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, ICAM1, KLF10, PIM3 +3 more	View in SCUBA

About the gene

Synonyms	FLJ23306, FRA2
Chromosome	2: 28392448-28417317
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.