T cell Quiescence
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
FOXO1 is a master transcription factor for T cell quiescence, memory, and homing. BCL6 is critical for memory T cell differentiation and is anti-inflammatory. AGO2 is the catalytic engine of RISC, driving miRNA-mediated gene silencing. NFE2L2 (NRF2) drives antioxidant response. PFKFB3 regulates glycolysis. IL21R is a cytokine receptor relevant to T cell biology. BRD1 and CSNK1D regulate chromatin and signaling. MCM6 suggests some S-phase activity. DHCR7 and SEC14L2 reflect lipid metabolism. FOXO1 and BCL6 together suggest a memory/quiescence transcriptional program in MAIT cells.
Genes
AGO2, AUTS2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1, GAL3ST2, GRAMD1B, IL21R, MCM6, NFE2L2, NFKB2, NINJ1, PBX4, PFKFB3, RTP5, SEC14L2, SMAP2, SURF4, ZDBF2
Most correlated modules
- NF-κB Activation · correlation 0.91
- cAMP Immune Regulation · correlation 0.88
- Hypoxia-ER Stress · correlation 0.87
- AP-1/MEF2 Activation · correlation 0.87
- Stress Granule Response · correlation 0.85
- Transcriptional Co-regulation · correlation 0.85
- Post-translational Regulation · correlation 0.81
- TCR Signal Attenuation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.