Late Activation Autophagy
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes GABARAPL1 (LC3-family, autophagosome formation — canonical autophagy), ISCA1 (iron-sulfur cluster assembly, mitochondrial quality), CREM (cAMP-responsive transcription, post-activation repression in T cells), DUSP8 (MAP kinase phosphatase, stress/JNK regulation), FOSL2 (AP-1 late-phase), BCL3 (NF-κB co-activator, late phase), RBM38 (mRNA stability), JOSD1 (deubiquitinase), FBXO33 (F-box ubiquitin ligase), PLK3 (stress-activated kinase). The constellation of GABARAPL1, CREM, DUSP8, and BCL3 points to a late/regulatory phase of activation featuring autophagy induction and negative feedback on proliferation/NF-κB. CREM is specifically known to act as a repressor of T cell activation late-phase. This module complements M142 (early activation) as a late/regulatory counterpart.
Genes
BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1, IRF2BP2, ISCA1, JOSD1, KBTBD2, KLF16, METRNL, MTFP1, NFE2L2, NXT1, OSER1, PLK3, RAB1A, RBM38, SELENOK, SYAP1, TENT4B, TNFSF9, VPS37B, ZBTB1, ZSWIM6
Most correlated modules
- NF-κB Activation · correlation 0.92
- TGF-beta Response · correlation 0.87
- Circadian Clock · correlation 0.87
- IFN-gamma Receptor Signaling · correlation 0.84
- TCR Early Activation · correlation 0.84
- ER Proteotoxic Stress · correlation 0.82
- TCR Threshold Regulation · correlation 0.82
- DNA Damage Ubiquitin · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.