Vasoactive GPCR Signaling
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes CALCRL, RAMP3 (CGRP/adrenomedullin receptor complex), APLNR (apelin receptor), CYSLTR1 (leukotriene receptor), and NOSTRIN (eNOS trafficking) collectively define a vasoactive GPCR and nitric oxide signaling program in endothelial cells. SPNS2 (S1P transporter), SCARB1 (lipid scavenger receptor), TGFBR2, and IGFBP4 further support vascular homeostasis signaling. The module is uniformly expressed across subsets, consistent with a general endothelial vascular tone program. Mild upregulation in UC remission suggests this is a homeostatic program partially suppressed during active inflammation.
Genes
APLNR, BAIAP2L1, CALCRL, COPZ2, CYSLTR1, ETS2, FAM110D, FAM167B, IFI16, IGFBP4, MYBBP1A, NOSTRIN, PKP4, RAMP3, SCARB1, SH2B2, SPNS2, TGFBR2, TMCC3
Most correlated modules
- Venous Endothelial Identity · correlation 0.76
- Quiescent Arterial EC · correlation 0.72
- Endothelial Quiescence Identity · correlation 0.70
- IL-27 Receptor Signaling · correlation 0.68
- Lipid Droplet Hypoxia · correlation 0.62
- Notch Ligand Signaling · correlation 0.59
- Immune Cell Contamination · correlation 0.57
- MHC Class II Presentation · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.