RAPGEF4 — Rap guanine nucleotide exchange factor 4
RAPGEF4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAPGEF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Angiogenic Endothelial Identity Endothelial cell development | ADAMTSL2, ARHGAP29, COL13A1, CTNNB1, EDIL3, EML1, ETS1, EXOC3L1 +14 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Pericytes | Basement Membrane Maintenance ECM production | CALCRL, DYSF, EXOC3L1, FAM167B, GRB10, HSPG2, PPM1F, RFLNB +1 more | View in SCUBA |
About the gene
| Synonyms | cAMP-GEFII, CGEF2 |
|---|---|
| Chromosome | 2: 172735274-173052893 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Exocytosis |
Function
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.