PPM1F — Protein phosphatase, Mg2+/Mn2+ dependent 1F
PPM1F belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPM1F's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1 +11 more | View in SCUBA |
| Pericytes | Basement Membrane Maintenance ECM production | CALCRL, DYSF, EXOC3L1, FAM167B, GRB10, HSPG2, RAPGEF4, RFLNB +1 more | View in SCUBA |
About the gene
| Synonyms | CAMKP, CaMKPase, FEM-2, KIAA0015, POPX2 |
|---|---|
| Chromosome | 22: 21919425-21952848 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Apoptosis |
Function
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.