CDHR2 — Cadherin related family member 2
CDHR2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDHR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush border lipid handling Absorption | ABCG1, ABHD12, ARL14, ENTPD8, IDS, PNPLA2, RAI14, SEMA3G +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ20124, FLJ20383, PC-LKC, PCDH24, PCLKC |
|---|---|
| Chromosome | 5: 176542511-176595974 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins |
| Biological process | Cell adhesion, Differentiation |
Function
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.