RAI14 — Retinoic acid induced 14
RAI14 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAI14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Endothelial Activation Inflammation | ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1 +8 more | View in SCUBA |
| Enterocytes | Brush border lipid handling Absorption | ABCG1, ABHD12, ARL14, CDHR2, ENTPD8, IDS, PNPLA2, SEMA3G +2 more | View in SCUBA |
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A +5 more | View in SCUBA |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RB1CC1 +4 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
| Pericytes | Actin Cytoskeletal Remodeling Cytoskeletal | CDC42EP1, DPYSL2, ETS1, FMNL3, HDAC1, LXN, ORAI2, SHC1 | View in SCUBA |
About the gene
| Synonyms | DKFZp564G013, KIAA1334, NORPEG, RAI13 |
|---|---|
| Chromosome | 5: 34656328-34832612 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Differentiation, Spermatogenesis |
Function
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood- testis barrier
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.