Type I Interferon Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes SAMD9 and SAMD9L are canonical antiviral restriction factors and type I IFN-stimulated genes that restrict viral replication and are induced by IFN-α/β. SP100 and SP110 are nuclear dot/PML body components and established ISGs. ISG15 is a prototypical type I IFN-stimulated ubiquitin-like modifier. DDX60L is an antiviral RNA helicase ISG. PARP12 is an ISG with antiviral activity. JAK2 mediates IFN signaling. This is distinct from M8 (IFN-γ/GBP-dominated) and represents a type I IFN antiviral restriction program. Enrichment in sen_colono alongside inf_colono may reflect IFN-driven senescence-associated antiviral state.
Genes
Most correlated modules
- TNF Apoptosis Resistance · correlation 0.90
- Senescent Colonocyte Differentiation · correlation 0.90
- TGF-β Chromatin Regulation · correlation 0.88
- IFN-γ Metabolic Reprogramming · correlation 0.86
- IFN-γ Antiviral Response · correlation 0.85
- Inflammasome Pyroptosis · correlation 0.85
- Junction Cytoskeletal Remodeling · correlation 0.84
- Senescent Cell Death · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.