SCUBA

IDS — Iduronate 2-sulfatase

IDS belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IDS's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActivation/Migration
BCR/AP1/NFKb pathway
AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, KLF6, LDLRAD4 +11 moreView in SCUBA
CD4⁺ T cellsGlucocorticoid Immunoregulation
Immune regulation
AHNAK, BTG1, CRIP1, GGNBP2, INSIG1, IRS2, JUND, KLF6 +11 moreView in SCUBA
EnterocytesBrush border lipid handling
Absorption
ABCG1, ABHD12, ARL14, CDHR2, ENTPD8, PNPLA2, RAI14, SEMA3G +2 moreView in SCUBA
Gamma-delta T cellsER Proteotoxic Stress
Stress
ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Hematopoietic progenitor cellsCytoskeletal Remodeling
Cytoskeletal
AHNAK, ANXA1, ATP2B1, DPYSL3, FHL1, MBOAT7, MTURN, PBXIP1 +5 more
Innate lymphoid cellsNF-κB Inflammatory Activation
Inflammation
CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 moreView in SCUBA
MacrophagesMixed Regulatory Signaling
Housekeeping
ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 moreView in SCUBA
Mucosal-associated invariant T cellNF-κB Negative Feedback
Immune regulation
ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, ITPRIP, NFKBIA, NFKBIB +7 more
Natural Killer cellsGlucocorticoid Response
Immune regulation
AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1 +11 moreView in SCUBA
NeutrophilsKLF2 Survival Response
Stress
BEST1, FOSB, JMJD1C, KLF2, KLF6, MYADM, RASSF5, YPEL5 +1 more

About the gene

SynonymsID2S, SIDS
ChromosomeX: 149476988-149521096
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular functionHydrolase

Function

Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.