KCNN3 — Potassium calcium-activated channel subfamily N member 3
KCNN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Caveolae-mediated Transcytosis Metabolite transfer | ADIPOR2, CAV1, CAV2, CCDC85A, CD320, EEPD1, EMP2, ENAH +19 more | View in SCUBA |
| Fibroblasts | Submucosal Fibroblast Developmental | ADAMTS19, ANGPTL7, C7, CHRDL1, DPT, GDF6, GPNMB, HAND2 +9 more | View in SCUBA |
| Lymphatic endothelial | Lymphangiogenesis ECM endothelial development | ARHGAP18, CEP68, CFI, DIPK2B, EGFL7, ELK3, ELN, FLT4 +10 more | View in SCUBA |
| Pericytes | Notch Vascular Development Developmental | ADAM15, ECSCR, HYAL2, ICAM2, JAG2, LYL1, MANSC1, NUDT14 +2 more | View in SCUBA |
About the gene
| Synonyms | hSK3, KCa2.3, SKCA3 |
|---|---|
| Chromosome | 1: 154697455-154870281 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calmodulin-binding, Ion channel |
| Biological process | Ion transport, Transport |
Function
Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening. The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens. Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). Does not function as a small conductance calcium-activated potassium channel (Probable). Selectively suppresses endogenous KCNN3 currents, in a dominant-negative fashion by decreasing the abundance of functional channels in the plasma membrane, possibly by selectively coassembling with and sequestering native KCNN3 protein in intracellular compartments. This dominant inhibitory effect extends to other members of the SK subfamily.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.