KAT6A — Lysine acetyltransferase 6A
KAT6A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KAT6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, MIER1 +12 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACIN1, ASH1L, BDP1, BLTP1, CLTC, EPS15, EXOC2, FAM120B +24 more | |
| Macrophages | Epigenetic Remodeling Housekeeping | AFF4, AGO3, AKAP13, ARID4B, ASH1L, CYTH1, ELF1, EPC1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more | |
| Pericytes | TGF-beta Negative Feedback Inflammatory | CTNND1, DAZAP2, EMP1, KBTBD2, KLF7, MLKL, RCAN1, RGS3 +6 more | View in SCUBA |
About the gene
| Synonyms | MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220 |
|---|---|
| Chromosome | 8: 41929479-42051994 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.