TGF-beta Negative Feedback
Gene co-expression module in Pericytes
| Category | Inflammatory |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
SKIL (SnoN) and SMURF2 are both canonical negative regulators of TGF-β/SMAD signaling: SKIL encodes SnoN which represses SMAD-mediated transcription, and SMURF2 is an E3 ubiquitin ligase that targets SMAD2/3 for degradation. RCAN1 regulates calcineurin/NFAT downstream of TGF-β. CTNND1 (p120-catenin) modulates adherens junctions in TGF-β-driven EMT contexts. RGS3 modulates GPCR signaling that intersects with TGF-β pathways. KLF7 and TCF4 are transcription factors regulated by TGF-β. KBTBD2 (BTB-Kelch ubiquitin adaptor) and TRIM56 (E3 ligase) suggest ubiquitin-mediated pathway regulation. This module represents TGF-β pathway negative feedback/regulation in pericytes, consistent with neighbors M69 (ENG/TAZ) and M27 (BMPR2) forming a TGF-β superfamily signaling neighborhood.
Genes
CTNND1, DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1, RGS3, SKIL, SMURF2, TCF4, TLNRD1, TNFAIP1, TRIM56
Most correlated modules
- BMP Receptor Signaling · correlation 0.97
- RAS Cytoskeletal Signaling · correlation 0.95
- YAP/TAZ Mechanosensing · correlation 0.95
- Vascular Junction Adhesion · correlation 0.94
- Arterial Notch Signaling · correlation 0.94
- G1 Cell Cycle Entry · correlation 0.94
- Actin-ERM Migration · correlation 0.94
- Angiogenic Receptor Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.