KBTBD2 — Kelch repeat and BTB domain containing 2
KBTBD2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KBTBD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more | |
| Pericytes | TGF-beta Negative Feedback Inflammatory | CTNND1, DAZAP2, EMP1, KAT6A, KLF7, MLKL, RCAN1, RGS3 +6 more | View in SCUBA |
About the gene
| Synonyms | BKLHD1, DKFZP566C134 |
|---|---|
| Chromosome | 7: 32868172-32894131 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.