Immunoproteasome Induction
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include immunoproteasome subunits PSMB8 (LMP7) and PSMB9 (LMP2), proteasome activator PSME2, ISGs IFI35, NMI, UBE2L6, NUB1, and LAP3 — all hallmarks of IFN-γ-driven antigen processing and ISG induction. TRAFD1 and LGALS9 further support interferon signaling. Neighbor M44 confirms an IFN-γ neighborhood; M8 specifically captures the immunoproteasome/antigen-processing arm.
Genes
CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2, NADK, NMI, NUB1, PSMB8, PSMB9, PSME2, SMCO4, SRI, SSB, TNFSF13B, TRAFD1, UBE2F, UBE2L6
Most correlated modules
- IFN-gamma Response · correlation 0.91
- Complex I / NADH Dehydrogenase · correlation 0.85
- Oxidative Phosphorylation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.