MHC-II antigen presentation
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Dominated by MHC class II antigen presentation and B-cell surface/signaling genes: HLA-DMA, HLA-DMB, HLA-DOA (MHC II peptide loading), plus B-cell markers CD53, CD81, LAPTM5, LAT2 (adaptor), DAPP1 (BCR signaling adaptor), FCRLA, HVCN1, GPR18. This is a B-cell antigen presentation / activation module. Uniform across B cells, no contamination. Induced with inflammation. Best label: MHC-II antigen presentation in B cells.
Genes
CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18, HLA-DMA, HLA-DMB, HLA-DOA, HVCN1, LAPTM5, LAT2, MEF2C, NIN, NSMCE3, OTUD1, RABAC1, SYPL1
Most correlated modules
- B Cell Identity Signaling · correlation 0.82
- B-cell activation signaling · correlation 0.81
- Naive B-cell identity · correlation 0.78
- B-cell signaling regulators · correlation 0.78
- BCR signaling/maturation · correlation 0.74
- B-cell activation · correlation 0.72
- Germinal center B-cell · correlation 0.72
- Chromatin modifiers · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.