DENND1B — DENN domain containing 1B
DENND1B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Immune regulation Immune regulation | FAM111A, GIT2, GOLGA8A, LPIN1, NLRC3, PPP2R5C, PSD4, RUFY3 +5 more | View in SCUBA |
| Enterocytes | Colonocyte differentiation TFs Chromatin regulation & transcription | AGAP1, ATXN1, DOCK5, GOLIM4, GRAMD2B, HNF4G, JMJD1C, LCORL +7 more | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2 +8 more |
About the gene
| Synonyms | C1orf218, FAM31B, FLJ20054, MGC27044 |
|---|---|
| Chromosome | 1: 197504748-197775696 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Protein transport, Transport |
Function
Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.