DAPK2 — Death associated protein kinase 2
DAPK2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DAPK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DOCK5 +15 more | View in SCUBA |
| Enterocytes | Junctional Hippo/TGF-beta signaling Migration & adhesion | AFDN, BACH1, CCNL1, DST, PELI2, SMAD3, UACA, WWC1 | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DENND1B +8 more | |
| Natural Killer cells | NK Checkpoint Receptors Immune regulation | CD7, CD96, CRACR2B, ECH1, ECI2, ISYNA1, KIR2DL4, MAP4 +5 more | View in SCUBA |
About the gene
| Synonyms | DRP-1, MGC119312 |
|---|---|
| Chromosome | 15: 63907036-64072033 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis |
Function
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.