DOCK5 — Dedicator of cytokinesis 5
DOCK5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2 +15 more | View in SCUBA |
| Enterocytes | Colonocyte differentiation TFs Chromatin regulation & transcription | AGAP1, ATXN1, DENND1B, GOLIM4, GRAMD2B, HNF4G, JMJD1C, LCORL +7 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, EML2 +14 more | |
| Glial cells | Glial Adhesion Cytoskeletal migration & adhesion | AKAP9, COL21A1, EPB41L2, KIAA1217, LTBP3, NCAM1, RALGPS2, SCN7A +1 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CERS6, CHST15, EPS15, FRMD4B, FRY, IL7, ITSN1 +4 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
About the gene
| Synonyms | FLJ21034 |
|---|---|
| Chromosome | 8: 25184689-25418082 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.