Butyrophilin gd Activation
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 25 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 25 genes have a known function matching the annotation |
Why this annotation
BTN3A1 and BTN3A3 (butyrophilin 3A family) are the key ligands recognized by Vgamma9Vdelta2 T cells for phosphoantigen-driven activation — highly specific to gd T cell biology. ARHGAP30, ARHGAP25, ARHGAP1, ARHGEF2 (multiple Rho GTPase regulators), SPN (CD43), GAB3 (hematopoietic adapter), SH3KBP1 (CIN85, endocytosis scaffold) form a coherent program of butyrophilin-mediated gd TCR activation coupled to Rho GTPase-dependent cytoskeletal remodeling.
Genes
ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1, BTN3A3, DENND4C, EPB41, ESYT1, GAB3, KIF2A, NCKAP1L, PAFAH2, PYHIN1, RAB5B, RBL2, SH3KBP1, SPN, SSR1, TES, TRANK1, USP28
Most correlated modules
- TCR Activation Signaling · correlation 0.91
- Antiviral ISG Response · correlation 0.88
- TGF-β Migration Program · correlation 0.84
- γδ T Cell Identity · correlation 0.82
- ER Glycoprotein Quality Control · correlation 0.82
- T Cell Identity Program · correlation 0.81
- Interferon Stimulated Genes · correlation 0.80
- ER Antigen Processing · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.