ARHGAP1 — Rho GTPase activating protein 1
ARHGAP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1, BTN3A3 +16 more | |
| Smooth muscle cells | KLF6/ZNF24 regulators Activation | ACSL3, CTBP2, KLF6, PLEKHA4, SCAF11, TNFAIP8L3, ZNF24 | View in SCUBA |
About the gene
| Synonyms | CDC42GAP, p50rhoGAP, RhoGAP |
|---|---|
| Chromosome | 11: 46677080-46700619 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | GTPase activation |
Function
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.