DLL4 — Delta like canonical Notch ligand 4
DLL4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DLL4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Notch Arterial Identity Endothelial cell development | ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, EFNA1, EFNB2, GADD45A +14 more | View in SCUBA |
| Pericytes | Arterial Notch Signaling Developmental | BCL6B, CYTH1, EFNB2, HEY1, MSX1, NEDD9, PNP, SGK1 +1 more | View in SCUBA |
About the gene
| Chromosome | 15: 40929340-40939073 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Differentiation, Neurogenesis, Notch signaling pathway, Sensory transduction, Vision |
Function
Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.