ADAMTS1 — ADAM metallopeptidase with thrombospondin type 1 motif 1
ADAMTS1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAMTS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Notch Arterial Identity Endothelial cell development | ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2, GADD45A +14 more | View in SCUBA |
| Smooth muscle cells | NR4A-ADAMTS Activation Stress | ADAMTS4, ADAMTS9, AVPR1A, DUSP8, HIPK2, KLF9, MYC, NR4A1 +5 more | View in SCUBA |
About the gene
| Synonyms | C3-C5, KIAA1346, METH1 |
|---|---|
| Chromosome | 21: 26835755-26845409 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Heparin-binding, Hydrolase, Metalloprotease, Protease |
Function
Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Also cleaves COMP. Has angiogenic inhibitor activity. May play a critical role in follicular rupture (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.