Arterial Notch Signaling
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include EFNB2 (ephrin-B2, canonical arterial endothelial/pericyte marker), DLL4 (Delta-like ligand 4, Notch ligand driving arterial specification), HEY1 (Notch transcriptional target, arterial identity), BCL6B (transcriptional repressor in vascular cells), SGK1 (serum/glucocorticoid-regulated kinase), THBD (thrombomodulin, anticoagulant endothelial marker), and NEDD9 (scaffold for migration/signaling). The EFNB2 + DLL4 + HEY1 triad is the canonical arterial Notch signaling axis. Neighbor M31 contains SOX17 and GATA2 (arterial TFs), strongly reinforcing arterial specification as the neighborhood theme. Downregulated in both UC and CD inflammation.
Genes
BCL6B, CYTH1, DLL4, EFNB2, HEY1, MSX1, NEDD9, PNP, SGK1, THBD
Most correlated modules
- Rho GTPase Signaling · correlation 0.95
- TGF-beta Negative Feedback · correlation 0.94
- Vascular Tone Homeostasis · correlation 0.94
- Notch Vascular Development · correlation 0.94
- Arterial Identity TFs · correlation 0.93
- EMT-like Remodeling · correlation 0.92
- Vascular Barrier Integrity · correlation 0.91
- Vascular Identity TFs · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.