Notch Arterial Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 23 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 20 genes have a known function matching the annotation |
Why this annotation
DLL4, HEY1, HES4, and NRARP are core Notch pathway components: DLL4 is the canonical Notch ligand in arterial endothelium, HEY1 and HES4 are direct Notch transcriptional targets, and NRARP is a Notch feedback regulator. EFNB2 is a defining arterial endothelial marker and Notch target. MSX1 is a homeobox transcription factor regulated by Notch/BMP signaling. ARID5A is a transcriptional co-activator linked to Notch and inflammatory contexts. HEXIM1 regulates transcriptional elongation. ADAMTS1 is a Notch-regulated metalloprotease. BTG1/BTG2 are anti-proliferative genes consistent with quiescent arterial identity. HBEGF is a Notch-regulated growth factor. RHOB modulates endothelial cell polarity. ID2 modulates Notch/BMP balance. The module is suppressed in inflammation and restored in remission, consistent with loss of arterial Notch identity during inflammatory angiogenesis and its recovery. IER5L and GADD45A are stress-response genes that may reflect a minor sub-program.
Genes
ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2, GADD45A, HBEGF, HES4, HEXIM1, HEY1, ID2, IER5L, INTS6, MSX1, NEDD9, NRARP, RHOB, SAT1, STC1, YBX3
Most correlated modules
- Shear Stress Response · correlation 0.75
- Heat Shock Response · correlation 0.60
- Integrated Stress Response · correlation 0.59
- Endothelial Quiescence · correlation 0.58
- Chronic Inflammatory Activation · correlation 0.56
- NF-κB Early Response · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.