PNP — Purine nucleoside phosphorylase
PNP belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PNP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more | View in SCUBA |
| Endothelial | Chronic Inflammatory Activation Inflammation | ABL2, ADAMTS9, DDX21, EMP1, FOSL2, HRH1, KRT10, LMNA +2 more | View in SCUBA |
| Innate lymphoid cells | ILC3 Transcriptional Identity Differentiation | ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2 +11 more | View in SCUBA |
| Monocytes | Integrin-mediated Migration Migration & adhesion | DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Anti-inflammatory Homing Tissue residence | ANXA1, GPR183, NASP, TAGLN2, TUBA1C, UBE2A, VIM, YWHAQ | |
| Pericytes | Arterial Notch Signaling Developmental | BCL6B, CYTH1, DLL4, EFNB2, HEY1, MSX1, NEDD9, SGK1 +1 more | View in SCUBA |
About the gene
| Synonyms | NP, PUNP |
|---|---|
| Chromosome | 14: 20461992-20477094 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Purine salvage |
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.