HEY1 — Hes related family bHLH transcription factor with YRPW motif 1
HEY1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HEY1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Notch Arterial Identity Endothelial cell development | ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 more | View in SCUBA |
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more | View in SCUBA |
| Pericytes | Arterial Notch Signaling Developmental | BCL6B, CYTH1, DLL4, EFNB2, MSX1, NEDD9, PNP, SGK1 +1 more | View in SCUBA |
About the gene
| Synonyms | bHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1 |
|---|---|
| Chromosome | 8: 79762371-79767857 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors, Transporters |
| Molecular function | Developmental protein, DNA-binding, Repressor |
| Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Function
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Involved in the regulation of liver cancer cells self-renewal.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.