EDEM1 — ER degradation enhancing alpha-mannosidase like protein 1
EDEM1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDEM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | NF-κB Activation Inflammatory | BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more | View in SCUBA |
About the gene
| Synonyms | EDEM, KIAA0212 |
|---|---|
| Chromosome | 3: 5187646-5219958 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Unfolded protein response |
Function
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan- independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.