ENPP4 — Ectonucleotide pyrophosphatase/phosphodiesterase 4
ENPP4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENPP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Quiescence Identity Endothelial cell development | ABCC4, ARHGAP5, C1orf115, FAM107A, GIT2, IFNAR2, LRRFIP1, MSI2 +8 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, FBXO9, GSAP, INPP4A +18 more | |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
About the gene
| Synonyms | AP3Aase, KIAA0879, NPP4 |
|---|---|
| Chromosome | 6: 46129989-46146688 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Blood coagulation, Hemostasis |
Function
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.