AFDN — Afadin, adherens junction formation factor
AFDN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AFDN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2, LIFR +11 more | View in SCUBA |
| Enterocytes | Junctional Hippo/TGF-beta signaling Migration & adhesion | BACH1, CCNL1, DAPK2, DST, PELI2, SMAD3, UACA, WWC1 | View in SCUBA |
About the gene
| Synonyms | AF-6, AF6, MLLT4 |
|---|---|
| Chromosome | 6: 167826893-167972023 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Biological process | Cell adhesion |
Function
Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.