FGD6 — FYVE, RhoGEF and PH domain containing 6
FGD6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FGD6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Dark-zone GC B-cell B cell maturation | BRWD1, CCDC144A, CCDC88A, CD38, LPP, MYBL1, MYO1E, RAPGEF5 +2 more | View in SCUBA |
| Endothelial | Lipid Droplet Hypoxia Stress | BNIP3, CEMIP2, CNN3, FCGRT, PLIN2, SNTB2, TSPAN4 | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, GUCY1A1, ITGA6, MDFIC, NAV1 +13 more | View in SCUBA |
About the gene
| Synonyms | FLJ11183, ZFYVE24 |
|---|---|
| Chromosome | 12: 95076749-95217482 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.