RHOBTB3 — Rho related BTB domain containing 3
RHOBTB3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RHOBTB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY +14 more | |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | CCAR1, ENAH, FNBP1L, KDM1A, LMO4, PAIP1, PBRM1, RTF1 +2 more | View in SCUBA |
| Macrophages | TGF-beta Signaling Inflammatory | APPL1, BBX, C6orf89, CCDC50, CREB3L2, HCLS1, NCKAP1L, NFIC +9 more | View in SCUBA |
| Pericytes | Pericyte Inflammatory Activation Inflammatory | BATF3, CRISPLD2, FILIP1L, KCNJ8, MARCKS, PAG1, PDGFA, RHOQ +3 more | View in SCUBA |
| Smooth muscle cells | ER Chaperone/UPR Protein processing & ER | CALR, CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR +3 more | View in SCUBA |
About the gene
| Synonyms | KIAA0878 |
|---|---|
| Chromosome | 5: 95713522-95824383 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Transport |
Function
Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.